The iSuperSEED team of the Center for Nanoscale Science (Penn State MRSEC) pursues compelling new research opportunities in applying Rules of Life principles to adapt the highly-sophisticated synthesis and assembly machinery of living systems to the production of new symmetry-enabled functional materials that cannot be synthesized or fabricated through conventional engineering methods. The research team will leverage plant biology research of the DOE-funded Center for Lignocellulose Structure and Formation (CLSF), which seeks a deeper understanding of the plant cell wall, in part by adapting methods of materials research in service of biology to conversely induce biological systems to create new materials.  As an initial step, the team will utilize genotype and extracellular environment to control the structure, composition, and crystalline order of cellulose across length scales in search of new modes of symmetry-enabled materials response such as piezoelectricity, ferroelectricity, and electro-optic effects.