As the human civilization becomes increasingly urban-centric, the vision of smart cities aims to provide better services by optimally using the available resources, minimizing the operational cost, and maximizing the safety and security. In this talk, I will focus on efficient management and cybersecurity of transportation systems in such smart cities – which create unique challenges and opportunities due to the presence of humans in the loop. I will also discuss some of the recent design frameworks explored to counter these challenges and exploit these opportunities.