Gaseous signaling molecules such as nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) have recently attracted growing attention due to their regulatory functions in the cardiovascular, nervous, and immune systems. My group is developing polymer-based delivery systems for these gas molecules to explore the therapeutic potential. In this talk, I will discuss how polymeric material design is being used to delivery of these gaseous molecules and impact biological functions in cardiomyocytes and vascular endothelial cells.